Brugada syndrome type 1

Brugada syndrome is an inherited condition associated with sudden cardiac death. It is autosomal dominant and most often affects the sodium channels, though other mutations have been found.

There are 3 ECG patterns associated with Brugada syndrome:

Type I: Coved ST elevation >=2mm in V1-V3 followed by a negative T wave.
Type II: Saddleback ST elevation.
Type III: Saddleback or coved ST elevation <2 mm. These ECG changes can be transient, e.g. appearing with fever, ischemia, medications, alcohol, hypothermia and hypokalemia. For diagnosis, type I changes must be present as well as a history of VF, VT (spontaneous or induced), syncope, nocturnal agonal breathing, or a family history of sudden cardiac death younger than 45 years old or similar coved ECG changes. Type 2 and 3 changes may warrant further investigation. Treatment includes ICD insertion.

See also: Brugada syndrome

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